Using published evidence, critically evaluate the prognostic and predictive value of
assessing microvessel density in tumour samples.
Measurement of various parameters of the blood and lymphatic microvasculature has
been variously reported to be useful or useless in helping a clinical team to assess the
prognosis of a given cancer and its potential response to different therapies. Using
evidence gleaned from published sources, discuss if, and why, this may not be a
widely used method.
Word limit: =3500 words (excluding references and tables/figures).
General essay guidance
The essay is intended to assess your in-depth understanding of a significant area of
cellular pathology. You will be expected to demonstrate ability in selective information
retrieval and the presentation of ideas within a logical and coherent structure.
The structure of the essay should follow that of a short review paper (as might
be prepared for publication):
? Introduction ?
o to set the scene or context for the essay; to present a hypothesis
or question for subsequent discussion
? Middle ?
o the critical exposition; the development of a concept(s); critical analysis
of the literature; logical development and flow; the use of illustrative
examples; the relevance of the information presented should be clear
o you may use up to three figures to illustrate your essay. These must be
relevant and should be referred to in the text. The figure legends should
be self-contained and brief. Figures should be integrated appropriately
into the text.
? End ?
o conclusion; loose ends tied; future developments in the subject area
o all sources must be referenced. You should use the Harvard system for
reference citation as described in the document “How to Cite
References” available from Blackboard. The essay should be word processed in 12 pt font and double-spaced. The
left margin should be offset for binding. The essay should be bound securely
to prevent page loss.
Note that at Masters level there are no ‘right’ answers and that you have an
element of freedom in the interpretation of the titles. The essay will be
assessed on the following broad categories:
? Content (the subject areas discussed; breadth and depth of coverage) ?
? Evidence of synthesis (expansion of didactic themes; link with work place
experience; extended reading; relevance to the theory and practice of
? Originality ?
? Appropriateness of examples used to illustrate concepts or the essay
? Logical progression and presentation of counterposing concepts ?
? Relevance ?
? Structure ?
? Accurate citations and the use of contemporary, relevant and
peer-reviewed references ?
? Presentation (word count; word processed; lack of typographical
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