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Discuss the pharmacokinetic environment of the patient below. Please illustrate the key systems and diseases and how the patient’s ability to metabolize and excrete medication differs from a healthy individual.
C.K. is a 73-year old female presenting to the Emergency Department with complaints of somnolence and anorexia for 36 hours. Recent 11 pound weight gain refractory to diuresis, LE edema, and nocturnal dyspnea (sleeps sitting), her past medical history is significant for atrial fibrillation, kidney dysfunction, and diabetes mellitus. Echocardiogram three months ago revealed ejection fraction of 18 percent.
Medication Profile
Pravastatin 10 mg po daily
Lisinopril 2.5 mg po daily
Digoxin 0.125 mg po daily
Warfarin 7.5 mg po daily
HCTZ 25 mg po daily
Metformin 1000 mg po BID
Uric acid 11, BUN 44 and SCr 1.8. ALT 375, AST 401, LDH 254 and albumin 3.1. Cholesterol 254 and LDL 185, HgA1c 10%
Assignment 3 Grading Criteria Maximum Points
Correctly identified dysfunctional organ systems that contribute to pharmacokinetic status. 15
Demonstrated understanding of altered response to medication secondary to dysfunctional organs. 15
Used vocabulary relevant to the current week’s topics. 5
Used correct spelling, grammar, and professional vocabulary. Cited all sources using APA format. 5
Total: 40

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